The group's first single, "Heaven", reached No. 1 on the Adult Contemporary chart, and No. 16 on the Billboard Hot 100, also crossing over even to the Hot Country Songs chart, where it peaked at No. 46. "Heaven" was featured in Guitar Hero: On Tour. In 2005 the song won a Grammy Award for Best Pop Performance by a Duo or Group with Vocal. Other songs nominated for Grammys include "More Than Love" and "Onda," both in 2006.
In 2005, the group recorded "I Don't Wanna Lose Your Love" with Carlos Santana for the Santana album All That I Am. Their 2006 album, Sacred, features the song "Outlaws". In a "closing of the circle," Enrique Garza Sr. sings the verse about the "missing outlaws, just like me." Willie Nelson, who is credited on the 2004 album, also provides a verse which makes reference to his hit "On the Road Again".
In 2007, Los Lonely Boys participated in Amnesty International's "Make Some Noise" project. Their cover of John Lennon's "Whatever Gets You thru the Night" is the second single from the "Instant Karma: The Amnesty International Campaign to Save Darfur." The song was released on iTunes on April 17, with the entire album available on June 12 courtesy of Warner Bros. Records. "Whatever Gets You thru the Night" is noteworthy as John Lennon's only US number one solo single while he was alive.
Their third studio album, Forgiven, was released on July 1, 2008. The album was recorded at East Side Stages in Austin and was produced by Steve Jordan. On October 23, 2008, Los Lonely Boys sang the national anthem to open game two of the 2008 World Series in St. Petersburg, Florida.
In March 2009, Los Lonely Boys left Sony/Epic and signed on with Austin-based Playing In Traffic Records. In March 2010, the group was awarded "Best Rock Band" in the Austin Music Awards.
The trio released a tribute EP titled 1969 on October 13, 2009, paying homage to the 40th anniversary of the titular year with covers of Santana's "Evil Ways", The Doors' "Roadhouse Blues", Blind Faith's "Well All Right", The Beatles' "She Came in Through the Bathroom Window", and Tony Joe White's "Polk Salad Annie." The EP was produced by Andy Johns and marked the first release on their new label.
Los Lonely Boys' yet-to-be-titled fourth studio album was originally slated to drop in fall 2010. However, due to bassist Jojo Garza's vocal cord injury, the album has been pushed back. The band also had to cancel a handful of tour dates in late April and early May, but has since resumed the tour.
